Endorphins and more particularly β-endorphin are neuropeptides produced by a complex metabolism and known for their important role in the sensation of pleasure and well-being.
The secretion of these opioid molecules (of cutaneous, intestinal or cerebral origin), constitutes a natural mechanism of fight against the pain and contributes to the sensation of well-being. Released in the circulation, β-endorphin has a systemic effect affecting the entire body. This secretion can be stimulated by several factors such as sport, temperature variations, mechanical pressure exerted on the skin (contact, massage ...). When its level increases sufficiently in the blood, β-endorphin gives the individual a quick and brief sensation of well-being. Various factors (aging, metabolic dysfunctions, degradation enzymes, etc.) reduce the synthesis and activity of β-endorphin. Usually β-endorphin disappears rapidly under the action of degradation enzymes hence the need to stabilize this molecule. In the skin, β-endorphin is protected from enzymatic degradation by a polysaccharide: heparan sulfate.
The "fleur de sel", flower of salt (Flos salis) comes from ecosystems in which live halophilic microalgae such as Diatoms like Cyclotella sp. which produce many mediators to communicate with each other.
In his book "Natural History", Pliny the Elder evokes for the first time the flower of salt (Flos salis): "This flower of salt produces a kind of oil as surprising as it may seem (Optimo ex eo, quod olei quamdam pinguitudinem reddit is enim etiam in dirty pinguitudo, quod miremu). There is fat even in salt! If he says. Pliny the Elder adds that it has no nutritive power but that it is relaxing, (relaxing), stimulating and can remedy the weariness (psychostimulant) "solvit in vino and aqua, acopis and smegmatis utilis" (Volume 31 of 37 volumes, chapter XLII).
Our studies have demonstrated what Pliny the Elder (died in 79 during the eruption of Vesuvius) had described in the first century of our era since the oily Flos salis extract, OESF™, induces the synthesis of β-endorphin. By enriching this extract, OESF™, with Padina pavonica extract, the synthesis of heparan sulfate is stimulated. Studies in cell culture also show that the expression of β-endorphin is preserved by the natural extract of Vanilla tahitensis. These results highlight a synergy between the natural extracts of f"leur de sel", Padina pavonica and Vanilla tahitensis allowing the protection and the availability of β-endorphin.